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Interaction

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CNS Depressants

The sedative effects of SOMA and other CNS depressants (e.g., alcohol, benzodiazepines, opioids, tricyclic antidepressants) may be additive. Therefore, caution should be exercised with patients who take more than one of these CNS depressants simultaneously. Concomitant use of SOMA and meprobamate, a metabolite of SOMA, is not recommended .

CYP2C19 Inhibitors and Inducers

Carisoprodol is metabolized in the liver by CYP2C19 to form meprobamate. Co-administration of CYP2C19 inhibitors, such as omeprazole or fluvoxamine, with SOMA could result in increased exposure of carisoprodol and decreased exposure of meprobamate. Co-administration of CYP2C19 inducers, such as rifampin or St. John’s Wort, with SOMA could result in decreased exposure of carisoprodol and increased exposure of meprobamate. Low dose aspirin also showed an induction effect on CYP2C19. The full pharmacological impact of these potential alterations of exposures in terms of either efficacy or safety of SOMA is unknown.

Drug Abuse And Dependence

SOMA is not a controlled substance. Discontinuation of carisoprodol in animals or in humans after chronic administration can produce withdrawal signs, and there are published case reports of human carisoprodol dependence.

In vitro studies demonstrate that carisoprodol elicits barbiturate-like effects. Animal behavioral studies indicate that carisoprodol produces rewarding effects. Monkeys self administer carisoprodol. Drug discrimination studies using rats indicate that carisoprodol has positive reinforcing and discriminative effects similar to barbital, meprobamate, and chlordiazepoxide.

5 drugs known to have a major interaction with carisoprodol

  • acetaminophen/propoxyphene
  • aspirin/caffeine/propoxyphene

 

B
  • Balacet (acetaminophen/propoxyphene)

 

D
  • Darvocet A500 (acetaminophen/propoxyphene)
  • Darvocet-N 100 (acetaminophen/propoxyphene)
  • Darvocet-N 50 (acetaminophen/propoxyphene)
  • Darvon (propoxyphene)
  • Darvon Compound 32 (aspirin/caffeine/propoxyphene)
  • Darvon Compound-65 (aspirin/caffeine/propoxyphene)
  • Darvon-N (propoxyphene)

 

P
  • PC-CAP (aspirin/caffeine/propoxyphene)
  • PP-Cap (propoxyphene)
  • Propacet 100 (acetaminophen/propoxyphene)
  • propoxyphene
  • Propoxyphene Compound 65 (aspirin/caffeine/propoxyphene)

 

S
  • sodium oxybate

 

T
  • Trycet (acetaminophen/propoxyphene)

 

W
  • Wygesic (acetaminophen/propoxyphene)

 

X
  • Xyrem (sodium oxybate)

DRUG INTERACTIONS: Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop or change the dosage of any medicine before checking with them first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: melatonin, other muscle relaxants (e.g., cyclobenzaprine, methocarbamol).

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-anxiety drugs (e.g., diazepam), anti-seizure drugs (e.g., carbamazepine), medicine for sleep (e.g., zolpidem, temazepam), narcotic pain relievers (e.g., codeine), psychiatric medications (e.g., phenothiazines such as chlorpromazine or tricyclics such as amitriptyline), tranquilizers. Alcoholic beverages will also increase the drowsiness effect.

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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